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Micotherapy Shiitake

Micotherapy Shiitake è un integratore che contiene il fungo Shiitake in polvere, di origine biologica, un rimedio tradizionalmente utilizzato per potenziare la risposta immunitaria attraverso l’azione sul microbiota intestinale e per il mantenimento della salute e del benessere psicofisico


90 capsule

Mdo d'uso

3 capsule al giorno preferibilmente lontano dai pasti


Micotherapy Shiitake è un integratore con azione prebiotica, ricco in molecole bioattive, micro e macronutrienti, minerali, aminoacidi, vitamine, enzimi, fibre e metaboliti secondari favorisce l’equilibrio del microbiota intestinale e della bocca, rivelandosi utile in caso di placca dentale, gengiviti e parodontiti.  Contiene elevati livelli di polisaccaridi (betaglucani) tra cui il Lentinan, un betaglucano ramificato (β 1-3 β 1-6) che ha evidenziato importanti proprietà di immunomodulazione. Una sostanza particolarmente efficace contenuta nello Shiitake è l’eritadenina, considerata il componente bioattivo più importante responsabile dell’abbassamento dei livelli di colesterolo.

Effetti principali

  • Prebiotico del cavo orale, aiuta a prevenire afte, gengiviti e parodontiti.

  • Utile integrazione naturale di vitamina D

Informazioni nutrizionali


Per dosaggio giornaliero

Shiitake sporophorum 1500 mg
Reperibilità prodotto

Codice parafarmaco: A925363905

Inserito nel registro degli integratori n°: codice 69251


ingredienti da agricoltura biologica (IT BIO 006) – Made in Europe

Xu Z, Meenu M, Xu B. Effects of UV-C treatment and ultrafine-grinding on the biotransformation of ergosterol to vitamin D(2), physiochemical properties, and antioxidant properties of shiitake and Jew’s ear. Food Chem. 2020 Mar 30;309:125738.

Zembron-Lacny A, Gajewski M, Naczk M, Siatkowski I Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. .J Physiol Pharmacol. 2013 Apr;64(2):249-54

Ki Nam Yoon, et al. Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats. Mycobiology 39(2) : 96-102 (2011)

Shoji Odani et al. The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes. Eur. J. Biochem. 262, 915±923 (1999) q FEBS 1999

Yeung KS, Gubili J. Shiitake Mushroom ( Lentinula edodes ). J Soc Integr Oncol . 2008;6(3):134-135.

Israilides C, Kletsas D, Arapoglou D, et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes . Phytomedicine . 2008;15(6-7):512-519.

Yin Y, Fu W, Fu M, He G, Traore L. The immune effects of edible fungus polysaccharides compounds in mice. Asia Pac J Clin Nutr . 2007;16(suppl 1):258-260.

Yu S, Weaver V, Martin K, Cantorna MT. The effects of whole mushrooms during inflammation. BMC Immunol . 2009;10:12.

Lee JY, Kim JY, Lee YG, Rhee MH, Hong EK, Cho JY. Molecular mechanism of macrophage activation by Exopolysaccharides from liquid culture of Lentinus edodes . J Microbiol Biotechnol . 2008;18(2):355-364.

Péter G, Károly V, Imre B, János F, Kaneko Y. Effects of lentian on cytotoxic functions of human lymphocytes. Immunopharmacol Immunotoxical . 1988;10(2):157-163.

Tani M, Tanimura H Yamaue H, et al. In vitro generation of activated natural killer cell sand cytotoxic macrophages with lentinan. Eur J Clin Pharmacol . 1992;42(6):623-627.

Arinaga S, Karimine N, Takamuku K, et al. Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. Int J Immunopharm . 1992;14(4):535-539.

1Arinaga S, Karimine N, Nanbara S, et al. Enhanced production of interleukin 1 and tumor necrosis factor by peripheral monocytes after lentinan administration in patients with gastric carcinoma. Int J Immunopharm . 1992;14(1):43-47.

1Zhou LD, Zhang QH, Zhang Y, Liu J, Cao YM. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses. Int Immunopharmacol . 2009;9(4):455-462.

Kaneko Y, Chihara G. Potentiation of host resistance against microbial infections by lentinan and its related polysaccharides. Adv Exp Med Biol . 1992;319:201-215.

Hearst R, Nelson D, McCollum G, et al. An examination of antibacterial and antifungal properties of constituents of Shiitake ( Lentinula edodes ) and oyster ( Pleurotus ostreatus ) mushrooms. Complement Ther Clin Pract . 2009;15(1):5-7.

Tochikura T, Nakashima H, Kaneko Y, Kobayashi N, Yamamoto N. Suppression of human immunodeficiency virus replication by 3’-azido-3’-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan. Jpn J Cancer Res . 1987;78(6):583-589.

Yoshida O, Nakashima H, Yoshida T, et al. Sulfation of the immunodulating polysacchraride lentinan: a novel strategy for antivirals to human immunodeficiency virus (HIV). Biochem Pharmacol . 1988;37(15);2887-2891.

Gordon M, Bihari B, Goolsby E, et al. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial. J Med . 1998;29:305-330.

Ngai PHK, Ng TB. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci . 2003;73(26):3363-3374.

Rivera A, Benavides OL, Rios-Motta J. (22E)-Ergosta-6,22-diene-3beta,5alpha,8alpha-triol: a new polyhydroxysterol isolated from Lentinus edodes (Shiitake). Nat Prod Res . 2009;23(3):293-300.

Chihara G. Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Dev Biol Stand . 1992;77:191-197.

Aalto-Korte K, Susitaival P, Kaminska R, Mäkinen-Kiljunen S. Occupational protein contact dermatitis from shiitake mushroom and demonstration of shiitake-specific immunoglobulin E. Contact Dermatitis . 2005;53(4):211-213.

Suzuki K, Tanaka H, Sugawara H, et al. Chronic hypersensitivity pneumonitis induced by Shiitake mushroom spores associated with lung cancer. Intern Med . 2001;40(11):1132-1135.

Mak RK, Wakelin SH. Shiitake dermatitis: the first case reported from a European country. Br J Dermatol . 2006;154(4):800-801.

Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J of Allergy Clin Immunol . 1998;101(5):613-620.

Ciric L et al. In Vitro Assessment of Shiitake Mushroom (Lentinula edodes) Extract for Its Antigingivitis Activity. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 507908, 7 pages

Signoretto C et al. Testing a Low Molecular Mass Fraction of a Mushroom (Lentinus edodes) Extract Formulated as an Oral Rinse in a Cohort of Volunteers. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 857987, 7 pages

Zaura E et al. The Effects of Fractions from Shiitake Mushroom on Composition and Cariogenicity of Dental Plaque Microcosms in an In Vitro Caries Model. Journal of Biomedicine and BiotechnologyVolume 2011 (2011), Article ID 135034, 10 pages

Lingstrom P et al. The Anticaries Effect of a Food Extract (Shiitake) in a Short-Term Clinical Study. Journal of Biomedicine and BiotechnologyVolume 2012 (2012), Article ID 217164, 10 pages

Venturini M et al. Antimicrobial Activity of Extracts of Edible Wild and Cultivated Mushrooms against Foodborne Bacterial Strains. Journal of Food Protection®, Number 8, August 2008, pp. 1544-1741 , pp. 1701-1706(6)

Bisen PS et al Lentinus edodes: A Macrofungus with Pharmacological Activities Current Medicinal Chemistry, 2010, 17, 2419-2430 2419

Ciric, Lena, et al. “In vitro assessment of shiitake mushroom (Lentinula edodes) extract for its antigingivitis activity.” BioMed Research International  (2011).

Signoretto, Caterina, et al. “The anti-adhesive mode of action of a purified mushroom (Lentinus edodes) extract with anticaries and antigingivitis properties in two oral bacterial pathogens.” BMC complementary and alternative medicine 14.1 (2014): 75.

Solmaz, Gulhas, et al. “Inhibitory and disruptive effects of shiitake mushroom (Lentinula edodes) essential oil extract on oral biofilms.” Jundishapur Journal of Microbiology 6.9 (2013).

Hearst, Rachel, et al. “An examination of antibacterial and antifungal properties of constituents of Shiitake (Lentinula edodes) and Oyster (Pleurotus ostreatus) mushrooms.” Complementary Therapies in Clinical Practice 15.1 (2009): 5-7.

Xiaoshuang Dai et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. Journal of the American College of Nutrition – Published online: 11 Apr 2015

Israilides, C., et al. “In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes.” Phytomedicine 15.6 (2008): 512-519.

Kim, Hwa-Young, et al. “A polysaccharide extracted from rice bran fermented with Lentinus edodes enhances natural killer cell activity and exhibits anticancer effects.” Journal of medicinal food 10.1 (2007): 25-31.

Yamac,M.,et al.(2008).Hypoglycemic Effect of Lentinus Strigosus (Schwein.)Fr. Crude Exopolysaccharide in Streptozotocin-Induced Diabetic Rats. Journal of Medicinal Food,11,513-517.

Yang, B.K., et al. (2002) Hypoglycemic Effect of a Lentinus edodes Exo-Polymer Produced from a Submerged Mycelial Culture. Bioscience, Biotechnology, and Biochemistry, 66, 937-942.

Jennifer Williams, et al. Mushrooms not only Produce Vitamin D2 but can also Produce Vitamin D3 and Vitamin D4 - FASEB J, Apr 2013; 27: 794.6

Ren G, Xu L, Lu T, Yin J. Structural characterization and antiviral activity of lentinan from Lentinus edodes mycelia against infectious hematopoietic necrosis virus. .Int J Biol Macromol. 2018 Aug;115:1202-1210.

Linee prodotti


Micotherapy è la linea di prodotti AVD Reform a base di funghi medicinali provenienti da coltivazioni biologiche certificate.